Wednesday, 31 August 2016

(98) Inheritance patterns


Basic Dimension

http://sexualreligion.blogspot.com/ 









https://medlineplus.gov/ency/article/002052.htm

Autosomal recessive


Autosomal recessive is one of several ways that a trait, disorder, or disease can be passed down through families.

An autosomal recessive disorder means two copies of an abnormal gene must be present in order for the disease or trait to develop.

Information

Inheriting a specific disease, condition, or trait depends on the type of chromosome that is affected. The two types are autosomal chromosomes and sex chromosomes. It also depends on whether the trait is dominant or recessive.

A mutation in a gene on one of the first 22 nonsex chromosomes can lead to an autosomal disorder.

Genes come in pairs. One gene in each pair comes from the mother, and the other gene comes from the father. Recessive inheritance means both genes in a pair must be abnormal to cause disease. People with only one defective gene in the pair are called carriers. These people are most often not affected with the condition. However, they can pass the abnormal gene to their children.

CHANCES OF INHERITING A TRAIT

If you are born to parents who carry the same autosomal recessive change (mutation), you have a 1 in 4 chance of inheriting the abnormal gene from both parents and developing the disease. You have a 50% (1 in 2) chance of inheriting one abnormal gene. This would make you a carrier.

In other words, for a child born to a couple who both carry the gene (but do not have signs of disease), the expected outcome for each pregnancy is:
A 25% chance that the child is born with two normal genes (normal)
A 50% chance that the child is born with one normal and one abnormal gene (carrier, without disease)
A 25% chance that the child is born with two abnormal genes (at risk for the disease)

Note: These outcomes do not mean that the children will definitely be carriers or be severely affected.



https://ghr.nlm.nih.gov/primer/inheritance/inheritancepatterns







http://www.telegraph.co.uk/culture/hay-festival/8544359/Hay-Festival-2011-Professor-risks-political-storm-over-Muslim-inbreeding.html

Hay Festival 2011: Professor risks political storm over Muslim 'inbreeding’


Prof Steve Jones, one of Britain’s most eminent scientists, has warned that the level of inbreeding among the nation’s Muslims is endangering the health of future generations.

The geneticist said that it was common in the Islamic world for men to marry their nieces and cousins. He said that Bradford has a particular problem and warned that it could affect the health of children born into these marriages.
“It is common in the Islamic world to marry your brother’s daughter, which is actually closer than marrying your cousin.(..) We should be concerned about that as there can be a lot of hidden genetic damage. Children are much more likely to get two copies of a damaged gene.

He added: “Bradford is very inbred. There is a huge amount of cousins marrying each other there.” Research in Bradford has found that babies born to Pakistani women are twice as likely to die in their first year as babies born to white mothers, with genetic problems linked to inbreeding identified as a “significant” cause.

Studies have found that within the city, more than 70 per cent of marriages are between relations, with more than half involving first cousins.


Due to this, the risks of what are called autosomal recessive disorders such as cystic fibrosis and spinal muscular atrophy is 18x higher, while the risk of death due to gruesome malformations is 10x higher.   

                                          -----------------------------------------------
http://www.telegraph.co.uk/news/health/children/11723308/First-cousin-marriages-in-Pakistani-communities-leading-to-appalling-disabilities-among-children.html
First cousin marriages in Pakistani communities leading to 'appalling' disabilities among children.
"You go to any such family and there will be four or five children, at least one or two of whom will have some disability. That is absolutely unacceptable, and if we cannot do anything about it, is it fair to the children?" 
First-cousin marriages, which are are legal in the UK, are practised within Britain’s Pakistani community, as well as among some Arab and African families. Medical data previously suggested that while British Pakistanis were responsible for 3 per cent of all births, they accounted for 30 per cent of British children born with a genetic illness.







Autosomal dominant









X-linked dominant





X-linked recessive






Y-linked






Codominant







Mitochondrial








Assumption 280: Three elements likely caused the emergence of the Muslim instinct, which is male as well as female kin bonded to inbreeding and incest. This mutational abnormality is unprecedented in other inbreeding cultures, which are only bonded in the male lineage and where females are refreshed completely every generation (chimps, bonobos, Australopithecus africanus, Neanderthals and Aboriginals). This can be seen from mtDNA which is the same for males but different for females:

1: Inbreeding promotes tribal identity by genetic immortality in descendants since the Homininae (7 Ma; 400cc), the primal human-creature religion. Tribal identity revives in Muslim cultures in Western society today. Tribal identity is male and female kin bonded.

2: And since Homo erectus (2 Ma; 900cc) inbreeding also promotes the earthly reincarnation of Muslim fathers into descendants of their children.

3: And last but not least on the Arabian Peninsula (50 ka; 1400cc; mtDNA L3N) inbreeding was the only way to survive without the possibility to exchange fresh juvenile females. The perpetuation of this behavior despite adequate fresh juvenile females indicates an inbreeding-instinct mutation.








[From the forests they took with them the habit to exchange juvenile females with other groups (chimps and bonobos). This is the well known hunters-gatherers effect found back also in Neanderthals: https://www.youtube.com/watch?v=ki3rWqtAf8o
(40:41/1:22:30)









But on the other hand they enhanced tribal identity beyond the male mitochondrial DNA by closing the exogamous mantle for women as in today's Islam.]






http://www.nature.com/news/2011/110601/full/news.2011.338.html

Teeth from ancient human ancestors suggest that females joined new social groups once they reached maturity.


A chemical analysis of australopithecine fossils ranging between roughly 1.8 million and 2.2 million years old from two South African caves finds that teeth thought to belong to females are more likely to have incorporated minerals from a distant region during formation than those from males.


"What that's telling us is that the females grew up somewhere else and they died in the caves," says Julia Lee-Thorp, an archaeological scientist at the University of Oxford, UK. 






Paranthropus robustus (2 Ma; 400cc)

A 2011 study using ratios of strontium isotopes in teeth suggested that Australopithecus africanus and P. robustus groups in southern Africa were patrilocal: females tended to settle farther from their region of birth than males did.













Appendix

http://reaganiterepublicanresistance.blogspot.nl/2014/09/50-generations-of-ill-advised.html


In Pakistan, the inbred-marriage numbers approach 70%. Even in England, more than half of Pakistani immigrants are married to their first cousins (where their birth defects are the thing of legend), while in Denmark the number of inbred Pakistani immigrants was found to be approximately 40%.

Other Muslim countries: 67% in Saudi Arabia, 64% in Jordan, and Kuwait, 63% in Sudan, 60% in Iraq, and 54% in the United Arab Emirates and Qatar.  

Due to this, the risks of what are called autosomal recessive disorders such as cystic fibrosis and spinal muscular atrophy is 18x higher, while the risk of death due to gruesome malformations is 10x higher. 


Other negative consequences of inbreeding include a 100% increase in the risk of still births and a 50% increase in the possibility that a child will die during labor.

And not that anybody will be surprised, but such inbred children typically score 10-16 pts lower IQ, while social abilities also develop at a dramatically slower pace.




                                        



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Sunday, 28 August 2016

(97) The Alpha male started inbreeding and incest


Basic Dimension

http://sexualreligion.blogspot.com/ 

Number Archive


Balanced sexual model of inbreeding and outbreeding:









Hominids (20 mya; 300 cc) lived in the trees and did not succumb much to inbreeding and incest because they interchanged juvenile females with groups in their immediate vicinity. This can still be seen by today's chimps and bonobos. In these cases females have different mitochondrial DNA than males which all have about the same mtDNA. (It is also seen with Neanderthals and Aborigines.)

For hominids, the alpha male was the strongest male with genes for optimal protection of the females. He mated with as many females as possible. Basically he had the best genes but still was dealing with a genetic monoculture in the group of higher mammals, only serving the immediate survival of the group: 


Unbalanced sexual model of inbreeding:





In the long run his genes would be overrepresented into his descendants which would lead to identical male nuclear DNA (nuDNA):  






But these effects are negligible because female nuDNA came from all kinds of tribes in the neighbourhood. Furthermore his time to reign was limited until a stronger male took power. Also the exogamous mantle of the group was permeable allowing females to be fertilized by foreign males. Since, in nature females guard genetic diversity:






Hence, in groups of higher mammals there's a natural counter-force that compensates for genetic monoculture, called genetic variation or genetic diversity:

Balanced sexual model of inbreeding and outbreeding:





Only in mammal groups there is a tension between inbreeding and outbreeding. If no groups are formed, nature is ruled completely by genetic diversity between pairs of individuals:


Assumption 193: The primal law of animal religion is the commandment: thou shalt reproduce in genetic diversity.





Religion and sexual culture

If sexual culture is in equilibrium as in Alpha male mammal groups there is no steering needed from religion (see assumption 259 below). Cultural development (sexual culture) is a flat line in time and place and its time derivative (religion) is zero:









Appendix:

Assumption 259: Human religion.

Sexual culture Y=f(t) is a function of time t. And religion controls sexual culture by a set of higher order time derivatives, from which it gets the information how to alter sexual culture.

This may look somewhat difficult but is very simple to understand. Think about the police (X=t) controlling the speed of cars (Y=f(t)). If cars drive too slow or too fast the police will interfere.

Now, instead of the curve of the speed of cars we take the curve of inbreeding and incest which results from the first humanlike culture [homininae (7 mya; 400cc)]. Then, we see the effects of inbreeding and incest as effects of sexual culture over time.

We know group identity is the aim of every religion, which means tribal self identity of males. For inbreeding cultures this means 'religion' promotes inbreeding. Then, at a rising curve tribal self-identity is promoted by more look-a-likes in the offspring and with a decreasing curve genetic group identity diminishes. Controlling this process of sexual culture over time is called 'religion'. 

We are sure the first humanlike religion was 'genetic immortality by inbreeding and incest'. Speech or symbolic thinking was not essential. It is exactly the same religion of Islamic culture. It is simply copying the genetic code of the tribe into the offspring as secure as possible. But this increase finds its limits in too many hereditary diseases such as autosomal recessive diseases. That's why 'religion' orders to capture new women slaves from time to time. But it is more complicated. 


SPACE AND TIME EFFECTING SEXUAL CULTURE

Sexual culture is influenced more by displacement in space than in time. Sexual culture of the hominoidae (20-15 mya; 300cc) did not alter in time since they always lived in the forests in the same place and on short interbreeding distances of other groups. 

In contrast the first humanlike cultures [homininae (7 mya; 400cc] left the trees in little groups and roamed through the savannas bipedally. Definitely their sexual culture changed into inbreeding and incest because these small and slow groups fell apart in Africa. 

From the forests they took with them the habit to exchange juvenile females with other groups (chimps and bonobos). This is the well known hunters-gatherers effect found back also in Neanderthals: https://www.youtube.com/watch?v=ki3rWqtAf8o
(40:41/1:22:30)










http://www.nature.com/news/2011/110601/full/news.2011.338.html

Teeth from ancient human ancestors suggest that females joined new social groups once they reached maturity.


A chemical analysis of australopithecine fossils ranging between roughly 1.8 million and 2.2 million years old from two South African caves finds that teeth thought to belong to females are more likely to have incorporated minerals from a distant region during formation than those from males.


"What that's telling us is that the females grew up somewhere else and they died in the caves," says Julia Lee-Thorp, an archaeological scientist at the University of Oxford, UK. 








But on the other hand they enhanced tribal identity beyond the male mitochondrial DNA by closing the exogamous mantle for women as in today's Islam.



GENETIC IMMORTALITY IN THE OFFSPRING

We are sure the first humanlike religion was 'genetic immortality in the offspring by inbreeding and incest'. This religion resulted in nowadays Islamic culture. The basic principle is simply to copy the genetic code of the tribe into the offspring as secure as possible. 

But a lot of things have changed meanwhile. Effects are confounded in the evolution, since pure tribal endogamy does not exist any longer. Even ethnic endogamy has been outpaced meanwhile and today's Islam consists mainly of religious endogamy, which is a form of exogamy for males but a prison for females, which are not allowed to pass through the endogamous mantle of Islam. And here we see the difference with early hominids and later Neanderthals: Islam blocks juvenile females the way to genetic diversity.

Blocking genetic diversity for females must be seen as a higher order time effect of human religion on sexual culture. Notice, only the first time derivative of sexual culture is natural and realistic. All higher order time derivatives will never become zero (striving to perpetual orgasm in Heaven) and will be magically confounded. As an example in the evolution inbreeding confounded with reincarnation into the (earthly) universe, whereby sufficient inbred bodies had to be made for all ancestors waiting for reincarnation. So, there is no natural relation between inbreeding and reincarnation, but there is irrational relation between inbreeding and the fiction of ancestors to reincarnate into inbred bodies of the offspring.








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Monday, 22 August 2016

(96) Mitochondrial DNA males and females

Basic Dimension

http://sexualreligion.blogspot.com/ 

Number Archive







Assumption 259: Human religion.

Sexual culture Y=f(t) is a function of time t. And religion controls sexual culture by a set of higher order time derivatives, from which it gets the information how to alter sexual culture.

This may look somewhat difficult but is very simple to understand. Think about the police (X=t) controlling the speed of cars (Y=f(t)). If cars drive too slow or too fast the police will interfere.

Now, instead of the curve of the speed of cars we take the curve of inbreeding and incest which results from the first humanlike culture [homininae (7 mya; 400cc)]. Then, we see the effects of inbreeding and incest as effects of sexual culture over time.

We know group identity is the aim of every religion. For inbreeding cultures this means tribal self-identity is promoted by inbreeding. So, at a rising curve tribal self-identity is promoted by more look-a-likes in the offspring and with a decreasing curve genetic group identity diminishes. Controlling this process of sexual culture over time is called 'religion'. 

We are sure the first humanlike religion was 'genetic immortality by inbreeding and incest'. Speech or symbolic thinking was not essential. It is exactly the same religion of Islamic culture. It is simply copying the genetic code of the tribe into the offspring as secure as possible. But this increase finds its limits in too many hereditary diseases such as autosomal recessive diseases. That's why 'religion' orders to capture new women slaves from time to time. But it is more complicated. 


SPACE AND TIME EFFECTING SEXUAL CULTURE

Sexual culture is influenced more by displacement in space than in time. Sexual culture of the hominoidae (20-15 mya; 300cc) did not alter in time since they always lived in the forests in the same place and on short interbreeding distances of other groups. 

In contrast the first humanlike cultures [homininae (7 mya; 400cc] left the trees in little groups and roamed through the savannas bipedally. Definitely their sexual culture changed into inbreeding and incest because these small and slow groups fell apart in Africa. 

From the forests they took with them the habit to exchange juvenile females with other groups (chimps and bonobos). This is the well known hunters-gatherers effect found back also in Neanderthals: https://www.youtube.com/watch?v=ki3rWqtAf8o
(40:41/1:22:30)





But on the other hand they enhanced tribal identity beyond the male mitochondrial DNA by closing the exogamous mantle for women as in today's Islam:


Assumption 280: Three elements likely caused the emergence of the Muslim instinct, which is male as well as female kin bonded to inbreeding and incest. This mutational abnormality is unprecedented in other inbreeding cultures, which are only bonded in the male lineage and where females are refreshed completely every generation (chimps, bonobos, Australopithecus africanus, Neanderthals and Aboriginals). This can be seen from mtDNA which is the same for males but different for females:

1: Inbreeding promotes tribal identity by genetic immortality in descendants since the Homininae (7 Ma; 400cc), the primal human-creature religion. Tribal identity revives in Muslim cultures in Western society today. Tribal identity is male and female kin bonded.

2: And since Homo erectus (2 Ma; 900cc) inbreeding also promotes the earthly reincarnation of Muslim fathers into descendants of their children.

3: And last but not least on the Arabian Peninsula (50 ka; 1400cc; mtDNA L3N) inbreeding was the only way to survive without the possibility to exchange fresh juvenile females. The perpetuation of this behavior despite adequate fresh juvenile females indicates an inbreeding-instinct mutation.














In Australia the aborigines were trapped in the ice age which took all the water out of the air and destroyed forests into deserts. Less food supply meant groups had to split into very small groups which were threatened by extinction caused by inbreeding. But the aborigines developed ceremonies in trade between groups in which they walked over big distances and also exchanged young females. That's why aborigines survived:

https://www.youtube.com/watch?v=Zf6mqttBQXc (No longer available)










http://www.nature.com/news/2011/110601/full/news.2011.338.html

Teeth from ancient human ancestors suggest that females joined new social groups once they reached maturity.


A chemical analysis of australopithecine fossils ranging between roughly 1.8 million and 2.2 million years old from two South African caves finds that teeth thought to belong to females are more likely to have incorporated minerals from a distant region during formation than those from males.


"What that's telling us is that the females grew up somewhere else and they died in the caves," says Julia Lee-Thorp, an archaeological scientist at the University of Oxford, UK. 






Paranthropus robustus (2 Ma; 400cc)

A 2011 study using ratios of strontium isotopes in teeth suggested that Australopithecus africanus and P. robustus groups in southern Africa were patrilocal: females tended to settle farther from their region of birth than males did.








GENETIC IMMORTALITY IN THE OFFSPRING

We are sure the first humanlike religion was 'genetic immortality in the offspring by inbreeding and incest'. This religion resulted in nowadays Islamic culture. The basic principle is simply to copy the genetic code of the tribe into the offspring as secure as possible. 

But a lot of things have changed meanwhile. Effects are confounded in the evolution, since pure tribal endogamy does not exist any longer. Even ethnic endogamy has been outpaced meanwhile and today's Islam consists mainly of religious endogamy, which is a form of exogamy for males but a prison for females, which are not allowed to pass through the endogamous mantle of Islam. And here we see the difference with early hominids and later Neanderthals: Islam blocks juvenile females the way to genetic diversity:









Blocking genetic diversity for females must be seen as a higher order time effect of human religion on sexual culture. Notice, only the first time derivative of sexual culture is natural and realistic. All higher order time derivatives will never become zero (striving to perpetual orgasm in Heaven) and will be magically confounded. As an example: in the evolution inbreeding confounded with reincarnation into the (earthly) universe, whereby sufficient inbred bodies had to be made for all ancestors waiting for reincarnation. So we see, there is no natural relation between inbreeding and reincarnation, but there is only an irrational relation between inbreeding and the fiction of ancestors to reincarnate into inbred bodies of the offspring.

Confounding of evolutionary stages of religion led to the cultural psychopathy of Islam. Notice Christianity lost the inbreeding instinct by outbreeding through their exogamous mantle.

The religious stages of human sexuality:











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